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FLASH GENE

Symbol

GTF2F1

contributors: mct - updated : 10-10-2012

HGNC name	general transcription factor IIF, polypeptide 1, 74kDa
HGNC id	4652

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly   thyroid       highly Nervous nerve cranial nerve     highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a central charged cluster domain (binding to SRF's activation domain)

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to C.elegans Co1f1.1

Homologene

FAMILY

TFIIF alpha subunit family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB
	it promotes transcription elongation
	increasing the average rate of RNA chain elongation across DNA templates
	required for transcriptional initiation by RNA polymerase II
	supports elongation and suppresses pausing by stabilizing the post-translocated elongation complex, in collaboration with TCEA1 (TCEA1 has a role in suppression of transient pausing)
	with POLR2G are involved in both early and late transcriptional stages (Cojocaru 2008)

CELLULAR PROCESS	nucleotide, transcription, initiation
	nucleotide, transcription, elongation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimer of an alpha and a beta subunit
	subunit of RNA polymerase II transcription initiation factor II F

INTERACTION

DNA

RNA

small molecule	cofactor,
	Mg2+

protein	RNA polymerase II, SRF (serum response factor)
	interacts with GTF2F2 and CTDP1
	has an important role in stabilizing GTF2B within the preinitiation complex and after transcription initiates
	importance of GTF2F1 in stabilizing GTF2B interaction with the transcription complex, and potentially GTF2F1 should also participate in the process of elongation termination
	POLR2M stabilizes poised polymerases while maintaining their responsiveness to CCNT1, suggesting that Mediator overcomes a POLR2M-mediated block of initiation by allowing GTF2F1 function
	POLR2M competes with GTF2F1 for binding to the RPB1 and RPB5 subunits of Pol II, thereby inhibiting an essential function of GTF2F1 in preinitiation complex assembly

cell & other

REGULATION

Other

critical target for SRF-activated transcription

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS