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FLASH GENE
Symbol APOBEC2 contributors: mct/npt/pgu - updated : 23-06-2010
HGNC name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
HGNC id 605
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cytidine deaminase motif
  • a C terminal leucine rich region
    • secondary structure two long alpha-helices of a monomer structure prevent the formation of a square-shaped tetramer and facilitate formation of the rod-shaped tetramer via head-to-head interactions of two APO2 dimers
    mono polymer tetramer
    HOMOLOGY
    intraspecies homolog to APOBEC1
    Homologene
    FAMILY
  • apolipoprotein B messenger RNA-editing enzyme catalytic (APOBEC) polypeptides family
  • cytidine and deoxycytidylate deaminase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • RNA-specific cytidine deaminase (probable C to U editing enzyme)
  • having a low intrinsic cytidine deaminase activity
  • cytidine deaminase interacting with APOBEC1 and A1CF to inhibit apoB mRNA editing, possibly through interaction with other protein components of the apoB RNA editing holoenzyme
  • playing a possible role in the pathophysiology of hepatic inflammation
  • essential for normal muscle development and maintenance of fiber-type ratios, but its molecular function remains to be identified, biochemical analyses doing not especially argue for any role in RNA editing
  • may deaminate a substrate other than a polynucleotide, or the possibility even remains that it might fulfill some structural role without displaying any deaminase activity at all (Sato 2010)
  • selective inhibitor of TGFB signaling, regulating left-right axis specification during early embryogenesis
    • CELLULAR PROCESS protein, editing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • catalytic polypeptide 2 component of mRNA editing enzyme
  • forms a rod-shaped tetramer that differs markedly from the square-shaped tetramer of the free nucleotide cytidine deaminase, with which APOBEC proteins share considerable sequence homology
    • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • zn2+
    • protein
  • interacts and heterodimerizes with both APOBEC1 and APOBEC1 complementation factor (A1CF)
    • cell & other
    REGULATION
    induced by by TGFB signaling
    Other transcriptionally regulated by NF-kappaB in hepatocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Apobec2-deficient mice harbor a markedly increased ratio of slow to fast fibers in soleus muscle and exhibit an &
    8764;15–20p100 reduction in body mass from birth onwards, with elderly mutant animals revealing clear histological evidence of a mild myopathy