| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
|
| loss of function
|
|
results in sensitivity to oxidative stress in Fanconi anemia |
| tumoral
|
|
| --over
|
|
in prostate cancer tissue  |
| tumoral
|
|
| --over
|
|
|
in primary Uveal melanoma (UM) tissue is associated with metastasis and poor survival |
| constitutional
|
|
| --low
|
|
|
decreased PRDX3 by excessive bile acids in trophoblasts plays a critical role in the pathogenesis and progression of Intrahepatic cholestasis of pregnancy (ICP) |
| constitutional
|
|
| --over
|
|
|
in prostatic epithelial cells may promote the initiation and development of Benign prostatic hyperplasia (BPH) through autophagy inhibition and pyroptosis activation |
