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FLASH GENE
Symbol PRDX3 contributors: /mct - updated : 12-12-2022
HGNC name peroxiredoxin 3
HGNC id 9354
ASSOCIATED DISORDERS
corresponding disease(s) PPPCD , SCAR32
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
results in sensitivity to oxidative stress in Fanconi anemia
tumoral     --over  
in prostate cancer tissue
tumoral     --over  
in primary Uveal melanoma (UM) tissue is associated with metastasis and poor survival
constitutional     --low  
decreased PRDX3 by excessive bile acids in trophoblasts plays a critical role in the pathogenesis and progression of Intrahepatic cholestasis of pregnancy (ICP)
constitutional     --over  
in prostatic epithelial cells may promote the initiation and development of Benign prostatic hyperplasia (BPH) through autophagy inhibition and pyroptosis activation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • positive association of plasma PRDX3 and insulin suggest PRDX3 to be a potential indicator of high insulin resistance
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    potential therapeutic target for HCC treatment
    neurologyacquired 
    may have potential therapeutic value for traumatic brain injury (TBI)
    ANIMAL & CELL MODELS