Symbol
| PRDX3
| contributors: /mct - updated : 12-12-2022
|
HGNC name
| peroxiredoxin 3
|
HGNC id
| 9354
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
|  
| loss of function
|
results in sensitivity to oxidative stress in Fanconi anemia | tumoral
|  
|  
| --over
|  
|
in prostate cancer tissue | tumoral
|  
|  
| --over
|  
|
in primary Uveal melanoma (UM) tissue is associated with metastasis and poor survival | constitutional
|  
|  
| --low
|  
|
decreased PRDX3 by excessive bile acids in trophoblasts plays a critical role in the pathogenesis and progression of Intrahepatic cholestasis of pregnancy (ICP) | constitutional
|  
|  
| --over
|  
|
in prostatic epithelial cells may promote the initiation and development of Benign prostatic hyperplasia (BPH) through autophagy inhibition and pyroptosis activation | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| positive association of plasma PRDX3 and insulin suggest PRDX3 to be a potential indicator of high insulin resistance | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | digestive | liver | |
potential therapeutic target for HCC treatment | neurology | acquired | | |
may have potential therapeutic value for traumatic brain injury (TBI) |
| | |