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FLASH GENE

Symbol

SEMA4D

contributors: mct/npt - updated : 03-11-2015

HGNC name	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
HGNC id	10732

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in patients with thrombotic disorders or on cardiac bypass tumoral     --over   in soft tissue sarcoma with poorer overall and disease-free survival (Ch'ng 2007)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     targeting SEMA4D function along with VEGFA could represent a novel anti-angiogenic therapeutic strategy for the treatment of solid tumors.

ANIMAL & CELL MODELS