| basic FUNCTION
| repellent of the nerve growth cone guidance |
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inducing B cell to aggregate and improving their viability in vitro |
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promotes angiogenesis, invasive growth, proliferation, and antiapoptosis of cancer cells (Ch'ng 2007) |
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stimulating axonal outgrowth of embryonic dorsal root ganglion (DRG) neurones in stead of retraction |
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in platelets, has roles in the response to vascular injury, is able to interact directly with receptors on nearby platelets, promoting thrombus formation on exposed collagen (Zhu 2007) |
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acting as a chemorepellant to the axons of retinal ganglion cells and hippocampal neurons (Fuchikawa 2009) |
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PTPN11-mediated tyrosine dephosphorylation is an important step in SEMA4D-induced axon repulsion (Fuchikawa 2009) |
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signaling requires the recruitment of PLC gamma into the PLXNB1 receptor complex (Swiercz 2009) |
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SEMA4D/PLXNB1 promotes the dephosphorylation and activation of PTEN through the RRas GAP activity, inducing growth cone collapse  |
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SEMA4D/PLXNB1-mediated NFKB1 activation and IL8 production is critical in the generation a pro-angiogenic phenotype in endothelial cells |
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role for PPLXNB1 in maintenance of melanocyte survival and proliferation in the skin, suggesting that SEMA4D and PLXNB1 act cooperatively with HGF and MET to regulate MET-dependent effects in human melanocytes |
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is a protective paracrine factor for normal human melanocyte survival in response to UV irradiation |
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PLXNB1 and SEMA4D cooperate to promote perineural invasion in a RHOA/ROK-dependent manner |
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plays a role in tumor-induced angiogenesis similar to vascular endothelial growth factor VEGFA |
