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FLASH GENE
Symbol PLA2G4C contributors: - updated : 21-09-2005
HGNC name phospholipase A2, group IVC (cytosolic, calcium-independent)
HGNC id 9037
Location 19q13.3      Physical location : 48.551.100 - 48.614.109
Synonym name
  • cytosolic phospholipase A2 gamma
  • phospholipase A2, cytosolic, calcium-independent,
  • Synonym symbol(s) CPLA2B
    DNA
    TYPE functioning gene
    STRUCTURE 62.00 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D19S425 - GPI - COX6B1 - D19S208 - D19S224 - SCN1B - D19S228 - D19S421 - RPS16 - D19S223 - D19S217 - CALM1 - D19S412 - D19S606 - FUT1 ,PLA2G4C - D19S907 - D19S917 - D19S418 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunespleen   highly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic domain lacking the C2 calcium binding domain of PLA2G2A
  • two consensus motifs for lipid modification a N terminal myristylation site
  • a C terminal prenylation site, putatively anchoring enzyme into the membrane
  • HOMOLOGY
    intraspecies homolog to PLA2G2A
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing important roles in remodeling and maintaining membrane phospholipids under various conditions, including oxidative stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism SNP , other
  • marker for 19q loss in glioma
  • SNP increasing the risk of schizophrenia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS