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FLASH GENE
Symbol PLA2G4C contributors: - updated : 21-09-2005
HGNC name phospholipase A2, group IVC (cytosolic, calcium-independent)
HGNC id 9037
Location 19q13.3      Physical location : 48.551.100 - 48.614.109
Synonym name
  • cytosolic phospholipase A2 gamma
  • phospholipase A2, cytosolic, calcium-independent,
  • Synonym symbol(s) CPLA2B
    DNA
    TYPE functioning gene
    STRUCTURE 62.00 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D19S425 - GPI - COX6B1 - D19S208 - D19S224 - SCN1B - D19S228 - D19S421 - RPS16 - D19S223 - D19S217 - CALM1 - D19S412 - D19S606 - FUT1 ,PLA2G4C - D19S907 - D19S917 - D19S418 - qter
    Authors Gene Map (98)
    Physical map
    MRG2 KPTN 19q13.3 kaptin (actin binding protein) NAPA 19q13.3 N-ethylmaleimide-sensitive factor attachment protein, alpha DKFZp434I1930 GLTSCR1 19q13.3 glioma tumor suppressor candidate region gene 1 EHD2 19p13.3 EH-domain containing 2 GLTSCR2 19q13.3 glioma tumor suppressor candidate region gene 2 SEPW1 19q13.3 selenoprotein W, 1 LOC390949 19 similar to 60S ribosomal protein L23a FLJ40321 19q13.33 FLJ40321 protein CRX 19q13.3 cone-rod homeobox SULT2A1 19q13.3 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1 ELSPBP1 19q13.33 epididymal sperm binding protein 1 CABP5 19q13.3 calcium binding protein 5 PLA2G4C 19q13.3 phospholipase A2, group IVC (cytosolic, calcium-independent) LIG1 19q13.3 ligase I, DNA, ATP-dependent LOC374920 19q13.33 hypothetical protein LOC374920 CARD8 19q13.33 caspase recruitment domain family, member 8 MGC17986 19q13.33 hypothetical protein MGC17986 FLJ32926 19q13.33 hypothetical protein FLJ32926 EMP3 19q13.3 epithelial membrane protein 3 FLJ10922 19q13.33 hypothetical protein FLJ10922 SYNGR4 19q13.3 synaptogyrin 4 KDELR1 19q13.2-q13.3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 GRIN2D 19q13.1-qter glutamate receptor, ionotropic, N-methyl D-aspartate 2D GRWD1 19q13.33 glutamate-rich WD repeat containing 1 KCNJ14 19q13 potassium inwardly-rectifying channel, subfamily J, member 14 PSCD2 19q13.3 pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) KIAA1883 SULT2B1 19q13.3 sulfotransferase family, cytosolic, 2B, member 1 FLJ20200 19q13.33 hypothetical protein FLJ20200 SPACA4 19q13.3-14 sperm acrosome associated 4 RPL18 19q13.3 ribosomal protein L18 SPHK2 19q13.2 sphingosine kinase 2 DBP 19q13.3 D site of albumin promoter (albumin D-box) binding protein CA11 19q13.3 carbonic anhydrase XI
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunespleen   highly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic domain lacking the C2 calcium binding domain of PLA2G2A
  • two consensus motifs for lipid modification a N terminal myristylation site
  • a C terminal prenylation site, putatively anchoring enzyme into the membrane
  • HOMOLOGY
    intraspecies homolog to PLA2G2A
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing important roles in remodeling and maintaining membrane phospholipids under various conditions, including oxidative stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism SNP , other
  • marker for 19q loss in glioma
  • SNP increasing the risk of schizophrenia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS