Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RELA

contributors: mct - updated : 09-04-2018

HGNC name	v-rel reticuloendotheliosis viral oncogene homolog A (avian)
HGNC id	9955

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   might represent an attempt by the placenta to compensate for elevations in intracellular calcium, possibly caused by hypoxia and/or apoptosis, in both pregnancies with uterine artery notching and preeclampsia tumoral     --over   associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia tumoral fusion       C11orf95-RELA fusions drive oncogenic NFKB signalling in ependymoma tumoral fusion       ZMYND8-RELA in acute erythroid leukemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	therapeutic target for chronic lymphocytic leukemia (Hewamana 2008)

ANIMAL & CELL MODELS

RelA/p65(-/-) murine fibroblasts immortalize at considerably faster rates than RelA/p65(+/+) cells suggesting that RELA might function to maintain cellular senescence by regulating genomic stability and DNA repair