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FLASH GENE
Symbol ENDOGL1 contributors: mct/npt - updated : 09-07-2008
HGNC name endonuclease G-like 1
HGNC id 3347
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to 'yeast Endonuclease G (EndoG)'
homolog to rattus Endogl1 (81.8 pc)
homolog to murine Endogl1 (82.9 pc)
Homologene
FAMILY
  • DNA/RNA non-specific endonuclease family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • acting as an endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single stranded DNA and 5'-3' exonuclease activity
  • involved in programmed cell death and normal cell proliferation
  • dimeric mitochondrial enzyme that displays 5'-3' exonuclease activity
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding, cofactor,
  • divalent metal cations
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS