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FLASH GENE

Symbol

ENDOGL1

contributors: mct/npt - updated : 09-07-2008

HGNC name	endonuclease G-like 1
HGNC id	3347

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       moderately   thyroid       highly Lymphoid/Immune spleen       moderately Nervous nerve       predominantly Reproductive male system testis     moderately Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to 'yeast Endonuclease G (EndoG)'
	homolog to rattus Endogl1 (81.8 pc)
	homolog to murine Endogl1 (82.9 pc)

Homologene

FAMILY

DNA/RNA non-specific endonuclease family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner

basic FUNCTION	acting as an endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single stranded DNA and 5'-3' exonuclease activity
	involved in programmed cell death and normal cell proliferation
	dimeric mitochondrial enzyme that displays 5'-3' exonuclease activity

CELLULAR PROCESS

nucleotide

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding, cofactor,
	divalent metal cations

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS