| basic FUNCTION
| having a role in intercellular transport and communication |
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required both for producing endocochlear potential and for the survival of hair cells in the mature cochlea |
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involved in the paracrine signaling within the epidermis |
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play an important role in cell-to-cell communication |
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play a crucial role in inner ear Ca2+ signaling: as hemichannels, they promote ATP release, sustaining long-range intercellular Ca2+ signals propagation  |
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both GJB2 and GJB6 play essential roles in normal cochlear functions |
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GJB2, and GJB6 have dramatically different temporal and cellular expression patterns during early postnatal cochlear development |
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functional role of GJC2 and GJB6 for interastrocytic, interoligodendrocytic, and panglial coupling, and both connexins are required for maintenance of myelin |
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is likely dispensable for cochlear functions |
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controls hippocampal excitatory synaptic transmission through modulation of astroglial glutamate transport, which directly alters synaptic glutamate levels |
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is a critical regulator of synaptic strength by controlling the synaptic location of astroglial processes |
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essential for normal repair following sensory cell loss |
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plays a critical role in skin health and hearing |
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exhibits unique characteristics including a long half-life when assembled into gap junctions |
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astroglial GJB6 is an important player in orchestrating neuronal network activity |
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is involved in basic cognitive processes and shapes synaptic and network activities |
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activity-dependent dynamics of GJB6 expression, perisynaptic localization, and functions |
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in the cochlea, GJB2, GJB6 largely co-assemble into heteromeric gap junctions, which connect adjacent non-sensory epithelial cells |
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presence of non-junctional GJB2/GJB6 oligomers within lipid raft-enriched tricellular junction sites |
