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FLASH GENE
Symbol SLC7A9 contributors: mct/npt - updated : 20-04-2010
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
HGNC id 11067
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane segments (12TM)
  • cytoplasmic N and C termini
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Slc7a9 (87.2pc)
    ortholog to murine Slc7a9 (86.9pc)
    Homologene
    FAMILY
  • solute carrier family 7, cationic amino-acid
  • amino acid-polyamine-organocation (APC) superfamily
    • CATEGORY signaling neurotransmitter , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text apical membrane of proximal tubule
    basic FUNCTION
  • involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity)
  • being responsible for the high-affinity reabsorption of cystine in the kidney tubule
  • involved in the reabsorption of L-citrulline in the kidney, at least in part, by mediating the apical membrane transport of L-citrulline in renal tubule cells (Mitsuoka 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text L-cystine transporter
    PATHWAY
    metabolism aminoacid
    signaling
    a component
  • BO+AT subunit heterodimerizing with 2BAT (SLC3A1) (disulfide-linked)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by the tyrosine kinase inhibitor
    inhibited by the protein kinase A activator
    ASSOCIATED DISORDERS
    corresponding disease(s) CSNU3
    Susceptibility to chronic kidney disease
    Variant & Polymorphism other rs4805834 associated with chronic kidney disease (Chambers 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Slc7a9-deficient mice (Feliubadalo, 2003)