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FLASH GENE

Symbol

CD79B

contributors: np/ - updated : 22-07-2006

HGNC name	CD79b molecule, immunoglobulin-associated beta
HGNC id	1699

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	AGM6 agammaglobulinemia 6
Location	17q23.3      Physical location : 62.006.097 - 62.009.704
Synonym name	immunoglobulin-associated B29 in B-cell membrane antigen receptor
	cell differentiation antigen CD79B
	CD79B antigen (immunoglobulin-associated beta)
	B-cell antigen receptor complex-associated protein beta chain
	immunoglobulin-associated B29 protein
Synonym symbol(s)	IGB, IGHB, B29

DNA

TYPE	functioning gene
STRUCTURE	3.61 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000626 6 splicing 1300 NP_000617 26.1 229 - Cragg, Koyama, Hashimoto (1995) NM_021602 5 splicing 988 NP_067613 14 125 up-regulated in B-CLL Cragg, Koyama, Hashimoto (1995) containing a 312 bp (104 amino acid) in-frame deletion in the coding region NM_001039933 6 - 1303 NP_001035022 - 230 - Kremyanskaya (2005)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   spleen       highly   tonsils       highly Reproductive male system prostate     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an immunoglobulin-like V-type domain (ITAM)

conjugated

GlycoP , PhosphoP

HOMOLOGY

interspecies	ortholog to murine Igb
	homolog to rattus Igb
	homolog to C.elegans Y119C1B.B

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

antigen , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION	encodes the Ig-beta protein of the B-cell antigen component
	associated to surface IgM-receptor, may be involved in signal transduction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component	B-cell antigen component
	heterodimer of alpha and beta chains, disulfide-linked

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

phosphorylated on tyrosine as a result of B cell activation

ASSOCIATED DISORDERS

corresponding disease(s)

AGM6

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS