basic FUNCTION
| involved in the structural organization of meiotic prophase chromosomes |
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required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division |
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acts as a linker between SYCP1 and SYCP3 and therefore would be the missing connecting link between lateral elements and transverse filaments essential for proper chromosome synapsis (Winkel 2009) |
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SYCP2 may act as a bridge that brings the Synaptonemal complex and centromere together |
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SYCP3 and the SYCP2 C terminus, form a compact core around which cohesin complexes, HORMADs, HORMAD1, and HORMAD2 and the N terminus of SYCP2 are arrayed |
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role of SYCP2 in human male fertility |