SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,cytosolic,microsome
|
text
| localizes to endosomes |
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is also found in the plasma membrane |
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seem exclusively localized in intracellular organelles such as mitochondrial |
basic FUNCTION
| playing a role in electroneural exchange of protons for Na+ and K+ across the mitochondrial inner membrane |
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contributing to organellar volume and calcium homeostasis |
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playing a role in pH regulation |
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regulatory protein in the endosomal recycling system in apical surface development |
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in mineralizing osteoblasts, slightly basic basal pHi is maintained, and external acid load is dissipated, by high-capacity Na(+) /H(+) exchange via SLC9A1 and SLC9A6 |
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regulates potentially clathrin-dependent endocytosis of transferrin via pH regulation |
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may play a unique, previously unrecognized, role at glutamatergic synapses that are important for learning and memory |