| basic FUNCTION
| ca2+ dependent activator protein for secretion, neural/endocrine specific cytosolic required for the exocytosis of secretory vesicles, phopholipid protein, specifically interacting with phosphotidylinositol 4,5 biphosphate |
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conserved calcium binding protein essential for late-stage exocytosis of neurotransmitters from synaptic terminals  |
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plays critical roles not only in Ca(2+)-dependent, regulated exocytosis but also in constitutive exocytosis downstream of vesicle docking |
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essential regulator of synaptic vesicle and large dense core vesicle priming in mammalian neurons and neuroendocrine cells |
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CADPs and CADPS2 promote monoamine uptake and storage mediated by the vesicular monoamine transporters SLC18A1 and SLC18A2 |
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functions in priming Ca(2+)-dependent vesicle exocytosis |
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required for optimal vesicle exocytosis in neurons and endocrine cells where it functions to prime the exocytic machinery for Ca(2+)-triggered fusion |
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somal CADPS plays an important role in DCV (dense-core vesicles) trafficking in the trans-Golgi network ( |
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functional role in the soma, a major subcellular localization site of CADPS in many cell types, in regulating DCV trafficking in the trans-Golgi network, via protein-protein interaction with ARF4/ARF5 in a GDP-dependent manner |
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regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals |
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possible involvement of somal CAPDS1 in DCV trafficking in the trans-Golgi network |
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. exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis |
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although CADPS and UNC13A play crucial roles in the priming stage of secretion, their functions are non-redundant |
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novel mode of binding between CAPS1 and syntaxin-1, which play a crucial role in neurosecretion |
