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FLASH GENE
Symbol CACNA2D2 contributors: mct - updated : 05-03-2014
HGNC name calcium channel, voltage-dependent, alpha 2/delta subunit 2
HGNC id 1400
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • disulfide linked glycoprotein complex formed by an integral alpha 2 chain
  • a delta chain embedded in the outer layer of the membrane
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • voltage-dependent calcium channel (VDCC), alpha 2-delta regulatory subunit
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the voltage gated calcium channel
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CACNA2D2 and KCNH8, appeared to be regulated by CTNNB1, although the binding of CTNNB1 to the regulatory sequences of these genes could not be confirmed
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility lung cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mutated in ducky mice with altered Purkinje cells