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FLASH GENE
Symbol CACNA2D2 contributors: mct - updated : 05-03-2014
HGNC name calcium channel, voltage-dependent, alpha 2/delta subunit 2
HGNC id 1400
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemtestis   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • disulfide linked glycoprotein complex formed by an integral alpha 2 chain
  • a delta chain embedded in the outer layer of the membrane
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • voltage-dependent calcium channel (VDCC), alpha 2-delta regulatory subunit
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the voltage gated calcium channel
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CACNA2D2 and KCNH8, appeared to be regulated by CTNNB1, although the binding of CTNNB1 to the regulatory sequences of these genes could not be confirmed
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility lung cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mutated in ducky mice with altered Purkinje cells