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FLASH GENE
Symbol PPIE contributors: mct - updated : 21/10/2008
HGNC name peptidylprolyl isomerase E (cyclophilin E)
HGNC id 9258
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an RNA recognition motif (RRM) domain, interacting with PHD3 domain of MLL
  • C-terminal cyclophilin domain that has peptidyl-proline isomerase (PPIase) activity
    • conjugated HemoP
    mono polymer monomer , complex
    HOMOLOGY
    interspecies homolog to rattus Ppie (97.7 pc)
    homolog to murine Ppie (98.3 pc)
    Homologene
    FAMILY
  • cyclophilin-type PPIase (peptidyl-prolyl cis-trans isomerase) family
  • PPIase E subfamily
  • immunophilin class M family
    • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text spliceosome
    basic FUNCTION
  • accelerating the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
  • may be involved in muscle- and brain-specific processes
  • may be involved in pre-mRNA splicing
  • negatively regulates the function of MLL
    • CELLULAR PROCESS nucleotide, transcription, regulation
    nucleotide, RNA splicing
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • identified in the spliceosome C complex
    • INTERACTION
    DNA
    RNA binding to poly(A)(+)RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
  • flavoprotein P450 oxidoreductase (POR)
  • binding to cyclosporin A
  • mediates downregulation of the expression of MLL target genes HOXC8, HOXA9, CDKN1B, and C-MYC, in a proline isomerase-dependent manner
    • cell & other
    REGULATION
    Other binding specifically to mRNA, namely poly(A)(+)RNA which stimulates its PPIase activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    amplified with MYCL1 in small cell lung cancer lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS