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FLASH GENE
Symbol KCNB2 contributors: mct/npt - updated : 21-01-2020
HGNC name potassium voltage-gated channel, Shab-related subfamily, member 2
HGNC id 6232
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature
  • TM domains 5 and 6, sensitive to changes in membrane potential
    • HOMOLOGY
    interspecies homolog to Drosophila Shab-related subfamily
    Homologene
    FAMILY
  • potassium channel, voltage-gated, shab-related subfamily
  • KCNB family of voltage-gated potassium channels
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in repolarization of excitable cells (Yan 2004)
  • playing a role in regulating the excitability of superior cervical ganglion neurons (Malin 2002)
  • kCNB1, KCNB2 are important regulators of neuronal excitability in mammalian brain
  • KCNB1 regulates insulin secretion in beta-cells and KCNB2 modulates somatostatin release in delta-cells
  • KCNB1, KCNB2 exhibit distinct responses to acute phosphorylation-dependent regulation in brain neurons in situ
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • key function of the pyruvate-isocitrate cycle is to maintain levels of KCNB2 expression sufficient to allow it to serve as a negative regulator of Kv channel activity
    • cell & other
    REGULATION
    Other modulated by KCNS2
    ASSOCIATED DISORDERS
    corresponding disease(s) NDSEA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS