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FLASH GENE

Symbol

ST8SIA2

contributors: mct - updated : 16-03-2011

HGNC name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
HGNC id	10870

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   down-regulation ofpolysialic acid during oligodendrocyte differentiation is a prerequisite for efficient myelination by mature oligodendrocytes

Susceptibility

to autism spectrum disorders to schizophrenia

Variant & Polymorphism SNP , other	rs3784730 associated with autism spectrum disorders
	variation in ST8SIA2 has been associated with risk for schizophrenia in Asian populations

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Inactivation of ST8SiaII in mice alters axonal targeting, involving hippocampal infrapyramidal mossy fibers, and the mice show increased exploration and diminished fear