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FLASH GENE
Symbol SPON1 contributors: mct - updated : 02-10-2013
HGNC name spondin 1, (f-spondin) extracellular matrix protein
HGNC id 11252
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a FS domain found in F-spondins, mindins, M-spondin and amphiF-spondin, with a presence of three disulfide bonds associated with the N- and C-termini of the domain and a highly conserved N-linked glycosylation site
  • a reeler, a spondin and six thrombospondin type 1 repeat domains
    • HOMOLOGY
    interspecies homolog to rattus F-spondin (Rn.7546)
    homolog to Drosophila fat-spondin
    homolog to C.elegans F10E7.4
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may have a role in the growth and guidance of axons
  • promoting factor for cementoblastic differentiation
  • attaches to the extracellular matrix and promotes axonal outgrowth
  • is a novel protein in osteoarthritis (OA) cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation via pathways that involve production of PGE2
  • secreted and extracellular matrix-attached protein that has been implicated in axonal pathfinding during neural development as well as in vascular remodelling in adult tissues
  • multi-domain extracellular matrix (ECM) protein and a contact-repellent molecule that directs axon outgrowth and cell migration during development
  • cementoblast specific gene, which could promote periodontal ligament cell lines
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • downregulates recruitment to the root side of periodontal tissue via LRP8 and inhibits differentiation of osteoclastic precursors
  • regulates the differentiation of cementoblast-like cell lines via BMP7 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in ovarian carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • positional candidate gene in blood pressure control in hypertensive humans
    • Marker
    Therapy target
    ANIMAL & CELL MODELS