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FLASH GENE

Symbol

SPON1

contributors: mct - updated : 02-10-2013

HGNC name	spondin 1, (f-spondin) extracellular matrix protein
HGNC id	11252

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	305.49 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D11S1307 - SPON1 - D11S1310 - MYOD1 - D11S902 - D11S921 - cen
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006108 16 - 5154 NP_006099 - 807 - -

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas       highly Nervous nerve cranial nerve     highly Reproductive male system prostate       Respiratory respiratory tract trachea     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a FS domain found in F-spondins, mindins, M-spondin and amphiF-spondin, with a presence of three disulfide bonds associated with the N- and C-termini of the domain and a highly conserved N-linked glycosylation site
	a reeler, a spondin and six thrombospondin type 1 repeat domains

HOMOLOGY

interspecies	homolog to rattus F-spondin (Rn.7546)
	homolog to Drosophila fat-spondin
	homolog to C.elegans F10E7.4

Homologene

FAMILY

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may have a role in the growth and guidance of axons
	promoting factor for cementoblastic differentiation
	attaches to the extracellular matrix and promotes axonal outgrowth
	is a novel protein in osteoarthritis (OA) cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation via pathways that involve production of PGE2
	secreted and extracellular matrix-attached protein that has been implicated in axonal pathfinding during neural development as well as in vascular remodelling in adult tissues
	multi-domain extracellular matrix (ECM) protein and a contact-repellent molecule that directs axon outgrowth and cell migration during development
	cementoblast specific gene, which could promote periodontal ligament cell lines

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	downregulates recruitment to the root side of periodontal tissue via LRP8 and inhibits differentiation of osteoclastic precursors
	regulates the differentiation of cementoblast-like cell lines via BMP7 expression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed in ovarian carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene	positional candidate gene in blood pressure control in hypertensive humans
Marker
Therapy target

ANIMAL & CELL MODELS