|
| DDR1-null mice have smooth muscle cells that display reduced attachment to collagen, reduced proliferation on collagen, reduced migration toward collagen, reduced MMP2 and MMP2 expression, and targeted disruption of the DDR1 gene reduced neointimal growth after carotid injury  | |
DDR1-null mice are viable but smaller in size, mutant females were unable to bear offspring, and unable unable to lactate which is caused by hyperproliferation and abnormal branching of mammary ducts |
|
mice DDR1(-/-) smooth muscle cell exhibited impaired attachment to and migration toward a type I collagen substrate and MMP-2 and MMP-9 activities were concomitantly reduced |