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FLASH GENE

Symbol

DDR1

contributors: mct/shn - updated : 14-06-2015

HGNC name	discoidin domain receptor tyrosine kinase 1
HGNC id	2730

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast, ovarian, esophageal, child brain tumors constitutional     --over   strongly increased in the obstructed kidney tumoral somatic mutation       occasionally mutated in lung cancer and leukemia

Susceptibility

to schizophrenia

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous urinary   Inhibition of DDR1 expression or activity may represent a novel therapeutic target against the progression of renal diseases immunology inflammatory   blockade of collagen-receptor DDR1 might serve as an important new therapeutic concept in progressive fibrotic and inflammatory diseases in the future neurology neurodegenerative   DDR1 and DDR2 inhibition is a potential target to clear neurotoxic proteins and reduce inflammation in neurodegeneration

ANIMAL & CELL MODELS

	DDR1-null mice have smooth muscle cells that display reduced attachment to collagen, reduced proliferation on collagen, reduced migration toward collagen, reduced MMP2 and MMP2 expression, and targeted disruption of the DDR1 gene reduced neointimal growth after carotid injury
	DDR1-null mice are viable but smaller in size, mutant females were unable to bear offspring, and unable unable to lactate which is caused by hyperproliferation and abnormal branching of mammary ducts
	mice DDR1(-/-) smooth muscle cell exhibited impaired attachment to and migration toward a type I collagen substrate and MMP-2 and MMP-9 activities were concomitantly reduced