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Symbol POLR2D contributors: mct/npt - updated : 28-04-2005
HGNC name polymerase (RNA) II (DNA directed) polypeptide D
HGNC id 9191
Location 2q14.3      Physical location : 128.603.840 - 128.615.729
Synonym name
  • DNA directed RNA polymerase 4
  • RNA polymerase II subunit B43
  • Synonym symbol(s) RBP4, HSRBP4, HSRPB4, RPB16
    EC.number 2.7.7.6
    DNA
    TYPE functioning gene
    STRUCTURE 11.89 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D2S110 - D2S347 - ERCC3 - D2S2296 - POLR2D - D2S2215 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2338 - 142 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Lymphoid/Immunelymph node    
    Reproductivefemale systemuteruscervix  
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic RPB4 RNA polymerase subunit family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • polymerase II, DNA directed
  • potential role for the heterodimer (POLR2G/POLR2D) in binding and stabilizing the nascent RNA transcript (Meka 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with POLR2G, form a heterodimer that protrudes from the 10-subunit core of the enzyme (Meka 2005)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS