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FLASH GENE
Symbol CXCR5 contributors: mct/npt/pgu - updated : 13-01-2010
HGNC name chemokine (C-X-C motif) receptor 5
HGNC id 1060
Location 11q23.3      Physical location : 118.754.540 - 118.766.970
Synonym name
  • monocyte-derived receptor 15
  • CxC chemokine receptor type 5
  • Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)
  • CD185 antigen
  • Synonym symbol(s) MDR15, CCR5, MGC117347, BLR1, CD185, CXC-R5
    DNA
    TYPE functioning gene
    STRUCTURE 12.43 kb     2 Exon(s)
    MAPPING cloned Y linked   status confirmed
    Map cen - D11S939 - CD3G - DLAT - HMBS - CXCR5 - D11S4104 - RPS25 - D11S924 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2828 41.96 372 - 2001 11688722
    upstream, in frame initiaion codon
    - - 2893 - 327 - 1992 1425907
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Lymphoid/Immunelymph node    
     tonsils    
    Nervousbraindiencephalonamygdala  
     nervespinal nervesciatic  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Lymphoid/Immunenatural killer
    Nervousoptic nerve
    cell lineage
    cell lines Burkitt lymphoma cell lines and mantle zone B cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments receptor
  • HOMOLOGY
    interspecies homolog to murine Blr1
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • chemokine receptor, directing B cell migration to defined lymphoid organs and spleen
  • required for normal development of secondary lymphoid tissue
  • plays a role in chronic lymphocytic leukemia cell (CLL) positioning and cognate interactions between CLL and CXCL13-secreting CD68+ accessory cells in lymphoid tissues
  • activating Ca2+ signaling and chemotaxis independently of inhibitory G proteins
  • maintaining B and T cell infiltrates and ectopic follicles in thyroid tissue from patients with autoimmune diseases
  • may participate in the establishment of B-cell dysfunctions during HIV-1 infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • CXCL13/CXCR5 signaling effect on shaping B-cell dynamics is an effective mechanism that enhances antigen encounter and BCR-triggered B-cell activation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand CXCL13 (mediated chemotaxis of neuroblasts in response to CXCL13)
  • interacting with GRB2 (specifically controls a branch of CXCR5 signaling in B cells that induces lymphotoxin beta transcription but not chemotaxis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with its ligand, CXCL13 in B-cell chronic lymphocytic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS