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FLASH GENE

Symbol

DNAJB2

contributors: - updated : 16-02-2005

HGNC name	DnaJ (Hsp40) homolog, subfamily B, member 2
HGNC id	5228

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q32-q34      Physical location : 220.144.039 - 220.151.622
Synonym name	neuronal cochaperone
	heat shock protein, neuronal DNAJ-like 1
Synonym symbol(s)	HSJ1,HSPF3

DNA

TYPE	functioning gene
STRUCTURE	7.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant a - splicing 1760 30.6 277 - Cheetham variant b - splicing 2879 38.8 351 - Cheetham

EXPRESSION

Type

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       lowly Digestive liver       moderately Endocrine pancreas       moderately Nervous brain       highly   brain diencephalon hypothalamus   predominantly   brain forebrain cerebral cortex frontal predominantly Reproductive male system prostate     highly Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal     Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a J domain
	two ubiquitin-interacting motif (UIM) repeats

HOMOLOGY

interspecies	homolog to E.coli DnaJ
	homolog to yeast S.cerevisiae SIS1

Homologene

FAMILY

DNAJ family of proteins

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION

basic FUNCTION

regulating HSP70

CELLULAR PROCESS

protein, post translation, folding

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS