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FLASH GENE
Symbol DNAJB2 contributors: - updated : 16-02-2005
HGNC name DnaJ (Hsp40) homolog, subfamily B, member 2
HGNC id 5228
Location 2q32-q34      Physical location : 220.144.039 - 220.151.622
Synonym name
  • neuronal cochaperone
  • heat shock protein, neuronal DNAJ-like 1
  • Synonym symbol(s) HSJ1,HSPF3
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1760 30.6 277 - Cheetham
    - splicing 2879 38.8 351 - Cheetham
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
    Digestiveliver   moderately
    Endocrinepancreas   moderately
    Nervousbrain   highly
     braindiencephalonhypothalamus predominantly
     brainforebraincerebral cortexfrontalpredominantly
    Reproductivemale systemprostate  highly
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a J domain
  • two ubiquitin-interacting motif (UIM) repeats
  • HOMOLOGY
    interspecies homolog to E.coli DnaJ
    homolog to yeast S.cerevisiae SIS1
    Homologene
    FAMILY DNAJ family of proteins
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION
    basic FUNCTION regulating HSP70
    CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS