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FLASH GENE
Symbol GNB4 contributors: mct - updated : 03-04-2013
HGNC name guanine nucleotide binding protein (G protein), beta polypeptide 4
HGNC id 20731
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal alpha-helical segment
  • seven WD (Trp-Asp) repeats
  • a propeller structure and two bromodomains
    • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat G protein beta family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • in stellate ganglion neurons, GNB2 and GNB4 normally maintain the coupling of Ca(2+) channels with the receptors, with the latter subtype responsible for maintaining the integrity of both pathways
  • plays a role in peripheral nerve regeneration, supporting its importance in peripheral nerve functioning
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • intron-1 haplotypes of GNB4 may serve as predictive markers for progression and survival of patients suffering from bladder cancer
    • Therapy target
    ANIMAL & CELL MODELS