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FLASH GENE

Symbol

GNB4

contributors: mct - updated : 03-04-2013

HGNC name	guanine nucleotide binding protein (G protein), beta polypeptide 4
HGNC id	20731

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021629 10 - 6428 NP_067642 37.4 340 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal alpha-helical segment
	seven WD (Trp-Asp) repeats
	a propeller structure and two bromodomains

HOMOLOGY

Homologene

FAMILY

WD repeat G protein beta family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus

basic FUNCTION	in stellate ganglion neurons, GNB2 and GNB4 normally maintain the coupling of Ca(2+) channels with the receptors, with the latter subtype responsible for maintaining the integrity of both pathways
	plays a role in peripheral nerve regeneration, supporting its importance in peripheral nerve functioning

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

guanine nucleotide binding

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	intron-1 haplotypes of GNB4 may serve as predictive markers for progression and survival of patients suffering from bladder cancer
Therapy target

ANIMAL & CELL MODELS