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FLASH GENE
Symbol GNB4 contributors: mct - updated : 03-04-2013
HGNC name guanine nucleotide binding protein (G protein), beta polypeptide 4
HGNC id 20731
Location 3q26.32      Physical location : 179.113.876 - 179.169.371
Synonym name
  • G protein beta-4 subunit
  • transducin beta chain 4
  • DNA
    TYPE functioning gene
    STRUCTURE 55.50 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • 33 single nucleotide polymorphisms located in exon 1 and intron 1 were identified and together with a common exon-4 polymorphism implemented in haplotype analysis, which resulted in the determination of distinct haplotype blocks
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 6428 37.4 340 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal alpha-helical segment
  • seven WD (Trp-Asp) repeats
  • a propeller structure and two bromodomains
  • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat G protein beta family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • in stellate ganglion neurons, GNB2 and GNB4 normally maintain the coupling of Ca(2+) channels with the receptors, with the latter subtype responsible for maintaining the integrity of both pathways
  • plays a role in peripheral nerve regeneration, supporting its importance in peripheral nerve functioning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • intron-1 haplotypes of GNB4 may serve as predictive markers for progression and survival of patients suffering from bladder cancer
  • Therapy target
    ANIMAL & CELL MODELS