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FLASH GENE
Symbol DOPEY2 contributors: mct - updated : 23-02-2015
HGNC name dopey family member 2
HGNC id 1291
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative transmembrane domain
  • C-terminus contains two highly conserved leucine-like zipper domains
    • HOMOLOGY
    interspecies homolog to C.elegans pad-1
    homolog to murine 2610510B01Rik
    homolog to C.elegans Y18D10A.13
    Homologene
    FAMILY Dopey leucine zipper-like family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may be playing a role in cell differentiation
  • may be contributing to neurological alterations responsible for mental retardation in Down syndrome patients
  • could play a role in brain morphogenesis
  • plays a potential role in functional brain alterations and in the pathogenesis of mental retardation in Down syndrome
    • CELLULAR PROCESS cell life, differentiation
    protein
    PHYSIOLOGICAL PROCESS development
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    when overexpressed, it could participate in neurological features and mental retardation observed in DS patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS