metal ion-dependent enzymes that regulate cellular signaling by metabolic inactivation of the ubiquitous second messengers cAMP and cGMP
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
signal transduction
a component
INTERACTION
DNA
RNA
small molecule
metal binding,
Mn2+ or Mg2+
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
Type
Gene Modification
Chromosome rearrangement
Protein expression
Protein Function
constitutional
 
 
--over
 
significantly higher in the reticulocytes and neutrophils of sickle cell disease individuals, compared to control cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
since elevation of haematopoietic intracellular cGMP may be beneficial in SCD (sickle cell disease), the relatively limited tissue distribution of PDE9A suggests that it could represent a novel drug target for SCD