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FLASH GENE

Symbol

CCKBR

contributors: mct/npt - updated : 20/09/2008

HGNC name	cholecystokinin B receptor
HGNC id	1571

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	12.40 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CCK-BRwt - - 1690 48 447 - Monstein exon a CCK-BRt - - - 44 - - Monstein CCK-BRtx - - - 40 - - Monstein

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Endocrine pancreas         Nervous brain         Reproductive male system testis     highly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments (7TM) receptor
	an ITIM-like motif required for interaction with PTPN11 and the activation of the AKT pathway

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	stimulating the phosphatidylinositol cycle and intracellular Ca2+ mobilization
	may have a role in the regulation of the circadian rhythm, the metabolism of cerebral cholesterol and in the regulation of the plasminogen system (Hansen 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

behavioral

text	modulator of anxiety, pain, inhibitor of dopamine mediator behaviors

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS