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FLASH GENE
Symbol UBE2E3 contributors: shn/npt - updated : 21-03-2015
HGNC name ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
HGNC id 12479
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved UBC domain of 150AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
  • U-box and RING domains
    • HOMOLOGY
    interspecies homolog to yeast UBC4/5
    ortholog to Ube2e3, Mus musculus
    ortholog to Ube2e3, rattus norvegicus
    Homologene
    FAMILY
  • E2 ubiquitin-conjugating enzyme family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • is potentially imported into nuclei by the transport receptor importin-11 (IPO11)
    • basic FUNCTION
  • catalyzes the covalent attachment of ubiquitin to other proteins
  • participates in the regulation of transepithelial sodium transport in renal cells
  • May be involved in cell growth arrest
  • shuttles between the nuclear and cytoplasmic compartments
  • modulates the balance between RPE cell proliferation and differentiation
  • in concert with substrate adaptors, engages activated CUL3 ligases, thus suggesting that class III E2s are novel regulators of cullin ligases
  • play an essential role in the proliferation of RPE cells
  • can enhance the transcriptional activity of endogenous NFE2L2 and Cys-136 and the active-site cysteine, Cys-145, jointly contribute to this regulation
  • implicated in the restoration of redox homeostasis following oxidative stress
    • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    protein, degradation
    PHYSIOLOGICAL PROCESS
    text protein modification, protein ubiquitination
    PATHWAY
    metabolism
    signaling
    a component
  • UBE2E3-RCBTB1 complex led to the discovery and characterization of the following novel interactions
  • UBE2E3 and NFE2L2 form a nuclear complex utilizing the DNA binding, Neh1 domain, of NFE2L2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IPO11
  • NEDD4L
  • binds an N-terminal domain of CUL3 requiring the first 57 amino acids, the same domain that binds to RCBTB1 and other substrate adaptors
  • interacting with CUL3 independent of a bridging RING-finger protein and can engage the neddylated (i.e., activated) form of CUL3
  • ubiquitin-conjugating enzyme that is a novel regulator of NFE2L2
  • bind both E2&
    • 8764; ubiquitin conjugates and substrates to facilitate transfer of the ubiquitin molecule
  • MUL1 is involved in multiple biological pathways, and the interaction of GABARAP with MUL1-UBE2E3 supports the role of MUL1 as an important regulator of mitophagy and provides a plausible mechanism for its function in this process
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS