basic FUNCTION
| acting as an ubiquitin specific protease |
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play a critical role in dorsoventral patterning through the BMP pathway |
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involved in the regulation of hypertrophic responses in cardiac muscle through transcriptional and post-translational modulation of FHL1 |
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functions in COP9 signalosome mediated regulation of protein degradation and cellular signaling through catalyzing the ubiquitin deconjugation reaction of a discrete number of substrates |
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required for TGFB1 and BMP responses in mammalian cells |
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critical for the occupancy of endogenous target promoters by the SMAD complex |
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a key component of the TGF-beta signaling pathway, and in glioblastoma pathogenesis as well |
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USP4 and USP15 extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action |
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a key regulator of cellular RE1-silencing transcription factor, REST |
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specifically deubiquitinates Keap1 |
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removes ubiquitin chains from target proteins and maintains protein stability |
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