Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol USP14 contributors: mct - updated : 18-10-2007
HGNC name ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
HGNC id 12612
Location 18p11.32      Physical location : 158.482 - 213.739
Synonym name
  • tRNA-guanine transglycosylase
  • Synonym symbol(s) TGT
    EC.number 3.1.2.15, 2.4.2.29
    DNA
    TYPE functioning gene
    STRUCTURE 55.00 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC388454 18 LOC388454 LOC260334 18p11 HSA18p11 beta-tubulin 4Q pseudogene IL9RP4 18p11.3 interleukin 9 receptor pseudogene 4 USP14 18p ubiquitin specific protease 14 (tRNA-guanine transglycosylase) THOC1 18p11.32 THO complex 1 COLEC12 18pter-p11.3 collectin sub-family member 12 LOC390821 18 LOC390821 CETN1 18p11.32 centrin, EF-hand protein, 1 CLUL1 18p11.32 clusterin-like 1 (retinal) TYMS 18p11.32 thymidylate synthetase HSRTSBETA 18p11.32 rTS beta protein YES1 18p11.31-p11.22 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 ADCYAP1 18p11.31 adenylate cyclase activating polypeptide 1 (pituitary) LOC388456 18 hypothetical gene supported by BC039671 C18orf2 18p11 chromosome 18 open reading frame 2 LOC390822 18 similar to RIKEN cDNA 4921525H23 FLJ23017 HEC 18p11.31 similar to RIKEN cDNA 4921525H23 LOC388457 18 hypothetical gene supported by BC006008 KIAA0650 18p11.31 hypothetical gene supported by BC006008 EMILIN2 18p11.3 elastin microfibril interfacer 2 LPIN2 18p11.31 lipin 2 LOC390823 18 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) MYOM1 18p11.32-p11.31 myomesin 1 (skelemin) 185kDa MRCL3 18p11.31 myosin regulatory light chain MRCL3 MRLC2 18p11.31 myosin regulatory light chain MRLC2 LOC204777 18p11.31 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) TGIF 18p11.3 TGFB-induced factor (TALE family homeobox) LOC390824 18 similar to hypothetical protein BC007436 DLGAP1 18p11.3 discs, large (Drosophila) homolog-associated protein 1 MGC11082 18p11.31 hypothetical protein MGC11082
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4156 55 494 - crimmins, 2006
  • 16 exons
  • - splicing 4051 52 459 - crimmins, 2006
  • 15 exons
  • lacking an alternate exon compared to variant 1, but maintains the reading frame
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveesophagus   highly
     liver   highly
     mouthtongue  highly
    Endocrineadrenal gland   highly
    Hearing/Equilibriumear   moderately
    Lymphoid/Immunelymph node   moderately
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix moderately
     male systemprostate  moderately
    Respiratoryrespiratory tracttrachea  moderately
    Skin/Tegumentskin   moderately
    Urinarybladder   predominantly
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text whole embryo, moderately in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ubiquitin-like domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to yeast ubp6
    homolog to rattus Usp14 (96.8 pc)
    homolog to murine Usp14 (97 pc)
    intraspecies paralog to ubiquitin specific protein proteases ubp
    Homologene
    FAMILY
  • deubiquitin family
  • peptidase C19 family
  • ubiquitin-specific processing (UBP) family of proteases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • acting as an ubiquitin specific protease, hydrolyzing isopeptide bonds between UB and folded protein domains such as additional UB mioetis or target proteins
  • acting as a tRNA guanine transglycosylase, queunine tRNA ribosyltransferase guanine insertion enzyme
  • player in the UPR by serving as a physiological inhibitor of ERAD under the non-stressed condition (Nagai 2009)
  • might also have catalytic and noncatalytic functions to modulate the degradation of proteins (Nagai 2009)
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism protein
    signaling
  • Ubl conjugation pathway
  • a component associated with proteasme the 26S
    INTERACTION
    DNA
    RNA
    small molecule
    protein directly binds to ERN1 and the interaction between ERN1 and USP14 is inhibited by ER stress (Nagai 2009)
    cell & other
    REGULATION
    activated by response to proteasome inhibition
    Other activated catalytically upon specific association with the 26S proteasome
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS