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FLASH GENE

Symbol

DDAH2

contributors: mct - updated : 07-10-2015

HGNC name	dimethylarginine dimethylaminohydrolase 2
HGNC id	2716

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   by hypermethylation in DDAH2 promoter is positively correlated to the dysfunction of endothelial progenitor cells (EPCs) in coronary artery disease patients

Susceptibility

to risk of developing myocardial infarction (MI) to chronic kidney disease

Variant & Polymorphism SNP	rs805304 C allele was associated with decreased risk of MI and decreased risk of obesity
	rs9267551 functional variant of the DDAH2 gene is associated with chronic kidney disease with carriers of the C allele having a lower risk of renal dysfunction independently from several confounders

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS