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FLASH GENE

Symbol

TRIM33

contributors: mct/npt/pgu - updated : 17-05-2019

HGNC name	tripartite motif-containing 33
HGNC id	16290

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       chimeric protein 5' - RET - TRIM33 - 3' in thyroid nodules tumoral       loss of function leads to the expansion of a subset of myeloid cells characterizing the myelodysplastic/myeloproliferative neoplasm

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	in the mouse embryos a low level of ubiquitous expression at midgestation, and higher expression levels within the brain and spinal cord epithelium at later developmental stages
	Trim33-deficient mouse bone marrow-derived macrophages display a strongly reduced three-dimensional amoeboid mobility in fibrous collagen gels