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FLASH GENE
Symbol CD5 contributors: mct/pgu - updated : 20-08-2013
HGNC name CD5 molecule
HGNC id 1685
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three extracellular scavenger receptor cysteine-rich domains (SRCR, group B)
  • forming a rod-like structure with domain 1 distal from the cell surface and separated from domain 2 and 3 by an O-glycosylated peptide linker region
  • an ITIM motif
  • a pseudo ITAM region that may play a crucial role in RASGAP mediated TCR downregulation, through a mechanism that involves the inactivation of ERK
  • distal cytoplasmic domain of CD5, including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via CBL
    • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Cd5
    intraspecies paralog to CD6
    Homologene
    FAMILY
    CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be acting as a receptor in regulating T-cell proliferation
  • protecting circulating tumor-antigen specific CTL for tumor-mediated activation-induced cell death
  • immunotyrosine-based inhibition motif-bearing receptor that antagonizes the overt T cell receptor activation response by recruiting inhibitory intracellular mediators such as PTPN6, RASA1, or CBL
  • functions as a negative regulator of TCR signaling during thymocyte development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of transmembrane glycoprotein (TM1)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CD72
  • interacting with PTPN6 and opposing actiavtion mediated by the B cell receptor
  • CD5 expression is associated with NFATC1 activity (and mildly STAT3 activity), indicating that CD5 controls IL10 secretion
  • CBL is an ubiquitin ligase that physically associates with CD5
    • cell & other
    REGULATION
    Other down-regulated by selection of the alternative exon 1B
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    microsatellite instability in mantle cell lymphoma and B-cell chronic lymphocytic leukemia
    Susceptibility to secondary progressive multiple sclerosis
    Variant & Polymorphism other
  • polymorphism in the promoter is associated with increased susceptibility to B-cell chronic lymphocytic leukemia and mantle cell lymphoma
    • Candidate gene
  • may be involved in malignant phenotype of chronic lymphocytic leukemia, due to its phosphorylation
    • Marker
    Therapy target
    ANIMAL & CELL MODELS