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FLASH GENE
Symbol CD5 contributors: mct/pgu - updated : 20-08-2013
HGNC name CD5 molecule
HGNC id 1685
DNA
TYPE functioning gene
SPECIAL FEATURE
text head to tail orientation with CD6
STRUCTURE 25.39 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   other
text structure a (TC)n(CA)n microsatellite in the 5' region
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
text two isoforms, using exon1A (protein expressed at the cell surface) or exon 1B (protein retained in the cytoplasm) (PMID: 18641338)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3180 67 495 - 2013 23376399
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three extracellular scavenger receptor cysteine-rich domains (SRCR, group B)
  • forming a rod-like structure with domain 1 distal from the cell surface and separated from domain 2 and 3 by an O-glycosylated peptide linker region
  • an ITIM motif
  • a pseudo ITAM region that may play a crucial role in RASGAP mediated TCR downregulation, through a mechanism that involves the inactivation of ERK
  • distal cytoplasmic domain of CD5, including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via CBL
    • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Cd5
    intraspecies paralog to CD6
    Homologene
    FAMILY
    CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be acting as a receptor in regulating T-cell proliferation
  • protecting circulating tumor-antigen specific CTL for tumor-mediated activation-induced cell death
  • immunotyrosine-based inhibition motif-bearing receptor that antagonizes the overt T cell receptor activation response by recruiting inhibitory intracellular mediators such as PTPN6, RASA1, or CBL
  • functions as a negative regulator of TCR signaling during thymocyte development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of transmembrane glycoprotein (TM1)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CD72
  • interacting with PTPN6 and opposing actiavtion mediated by the B cell receptor
  • CD5 expression is associated with NFATC1 activity (and mildly STAT3 activity), indicating that CD5 controls IL10 secretion
  • CBL is an ubiquitin ligase that physically associates with CD5
    • cell & other
    REGULATION
    Other down-regulated by selection of the alternative exon 1B
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    microsatellite instability in mantle cell lymphoma and B-cell chronic lymphocytic leukemia
    Susceptibility to secondary progressive multiple sclerosis
    Variant & Polymorphism other
  • polymorphism in the promoter is associated with increased susceptibility to B-cell chronic lymphocytic leukemia and mantle cell lymphoma
    • Candidate gene
  • may be involved in malignant phenotype of chronic lymphocytic leukemia, due to its phosphorylation
    • Marker
    Therapy target
    ANIMAL & CELL MODELS