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FLASH GENE
Symbol AGAP1 contributors: mct/npt - updated : 08-04-2015
HGNC name ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
HGNC id 16922
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ATP/GTP binding site motif A (P-loop)
  • three ANK repeat
  • a ARF-GAP domain
  • a G-protein-like domain (GLD) with homology to Ras superfamily proteins
  • a PH domain
    • HOMOLOGY
    intraspecies paralog to CENTG1
    Homologene
    FAMILY
  • RAS superfamily
  • centaurin gamma-like family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • small GTPase mediating PI3K related Arf signalling
  • GTPase-activating protein for the adp ribosylation factor family
  • potential role in integrating signals from ARF, NO/cGMP, and tyrosine kinase signaling pathways
  • guanosine triphosphatase activating protein involved in the regulation of endosome function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • nuclear PI3K
  • interacting with G protein-coupled receptor kinases
  • associated with paxillin
  • also interacts with PIX exchange factors
  • associate with the adaptor protein complex AP-3 and regulate the function of AP-3 endosome
  • direct physical interaction between CHRM5 and the AP-3 adaptor complex regulator AGAP1
  • AGAP1 and AGAP2 can bind to RHOA
    • cell & other
    REGULATION
    Other allosterically regulated through protein binding to the GLD domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS