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FLASH GENE

Symbol

CARS

contributors: mct - updated : 08-04-2019

HGNC name	cysteinyl-tRNA synthetase
HGNC id	1493

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CARSD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     fused with ALK in t(2;11;2) (p23;p15;q31) in inflammatory mesenchymal tumors

Susceptibility

to immune disease polymyositis/dermatomyositis susceptibility to diabetic nephropathy in type 1 diabetes

Variant & Polymorphism SNP , other	strong association was identified at the CARS (cysteinyl-tRNA synthetase) locus with susceptibility to diabetic nephropathy in type 1 diabetes

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS