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FLASH GENE
Symbol CARS contributors: mct - updated : 08-04-2019
HGNC name cysteinyl-tRNA synthetase
HGNC id 1493
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Cars
Homologene
FAMILY aminoacyl-tRNA synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases
  • loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
  • is the sole enzyme responsible for charging tRNACys molecules in the cytoplasm of mammalian cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to tRNA
    small molecule metal binding,
    one zinc ion per subunit
    protein cysteine
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CARSD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    fused with ALK in t(2;11;2) (p23;p15;q31) in inflammatory mesenchymal tumors
    Susceptibility
  • to immune disease polymyositis/dermatomyositis
  • susceptibility to diabetic nephropathy in type 1 diabetes
    • Variant & Polymorphism SNP , other
  • strong association was identified at the CARS (cysteinyl-tRNA synthetase) locus with susceptibility to diabetic nephropathy in type 1 diabetes
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS