Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CARS contributors: mct - updated : 08-04-2019
HGNC name cysteinyl-tRNA synthetase
HGNC id 1493
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Cars
Homologene
FAMILY aminoacyl-tRNA synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases
  • loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
  • is the sole enzyme responsible for charging tRNACys molecules in the cytoplasm of mammalian cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to tRNA
    small molecule metal binding,
    one zinc ion per subunit
    protein cysteine
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CARSD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    fused with ALK in t(2;11;2) (p23;p15;q31) in inflammatory mesenchymal tumors
    Susceptibility
  • to immune disease polymyositis/dermatomyositis
  • susceptibility to diabetic nephropathy in type 1 diabetes
    • Variant & Polymorphism SNP , other
  • strong association was identified at the CARS (cysteinyl-tRNA synthetase) locus with susceptibility to diabetic nephropathy in type 1 diabetes
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS