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FLASH GENE

Symbol

CARS

contributors: mct - updated : 08-04-2019

HGNC name	cysteinyl-tRNA synthetase
HGNC id	1493

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	56.53 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001751 22 splicing 2550 NP_001742 - 748 - 2016 26184909 unique 44 AAs C terminus NM_139273 22 splicing 2558 NP_644802 - 726 - 2016 26184909 unique 22 AAs C terminus NM_001014437 23 - 2799 NP_001014437 - 831 - 2016 26184909 NM_001194997 23 - 2807 NP_001181926 - 809 - 2016 26184909

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Urinary kidney       highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

interspecies

homolog to murine Cars

Homologene

FAMILY

aminoacyl-tRNA synthetase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases
	loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
	is the sole enzyme responsible for charging tRNACys molecules in the cytoplasm of mammalian cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA	binding to tRNA

small molecule	metal binding,
	one zinc ion per subunit

protein

cysteine

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CARSD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     fused with ALK in t(2;11;2) (p23;p15;q31) in inflammatory mesenchymal tumors

Susceptibility

to immune disease polymyositis/dermatomyositis susceptibility to diabetic nephropathy in type 1 diabetes

Variant & Polymorphism SNP , other	strong association was identified at the CARS (cysteinyl-tRNA synthetase) locus with susceptibility to diabetic nephropathy in type 1 diabetes

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS