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FLASH GENE
Symbol PPM1E contributors: - updated : 10-10-2006
HGNC name protein phosphatase 1E (PP2C domain containing)
HGNC id 19322
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one phosphatase 2C motif
  • one phosphatase domain
  • a cluster of glutamate residues and a cluster of proline residues
    • mono polymer heteromer , trimer
    HOMOLOGY
    intraspecies homolog to CAMKP
    Homologene
    FAMILY PP2C family of Ser/Thr protein phosphatases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • blocking the effects of PAK, and thus inhibiting actin stress fiber breakdown and morphological changes driven by cell division cycle 42
  • regulating the phosphorylation level of GAPDH in the CaMKP-GAPDH complex by dephosphorylating and deactivating CaMKs that are responsible for the phosphorylation of GAPDH
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • could form an heterotrimeric complex with PPM1F and PAK1
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    manganese (Mn2+)
    protein interacting with PIX
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS