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FLASH GENE
Symbol PPM1E contributors: - updated : 10-10-2006
HGNC name protein phosphatase 1E (PP2C domain containing)
HGNC id 19322
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreasislet of Langerhans   
Nervousbraindiencephalonamygdala highly
 nerve   highly
Reproductivemale systemtestis  highly
Urinarykidney    
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one phosphatase 2C motif
  • one phosphatase domain
  • a cluster of glutamate residues and a cluster of proline residues
    • mono polymer heteromer , trimer
    HOMOLOGY
    intraspecies homolog to CAMKP
    Homologene
    FAMILY PP2C family of Ser/Thr protein phosphatases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • blocking the effects of PAK, and thus inhibiting actin stress fiber breakdown and morphological changes driven by cell division cycle 42
  • regulating the phosphorylation level of GAPDH in the CaMKP-GAPDH complex by dephosphorylating and deactivating CaMKs that are responsible for the phosphorylation of GAPDH
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • could form an heterotrimeric complex with PPM1F and PAK1
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    manganese (Mn2+)
    protein interacting with PIX
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS