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FLASH GENE
Symbol PPM1E contributors: - updated : 10-10-2006
HGNC name protein phosphatase 1E (PP2C domain containing)
HGNC id 19322
Location 17q23.2      Physical location : 56.833.231 - 57.062.532
Synonym name
  • CAMKP-related protein
  • partner of PIX 1
  • protein phosphatase 2C
  • calmodulin-dependent protein kinase phosphatase N
  • Synonym symbol(s) KIAA1072, POPX1, PP2CH , CAMKPN,
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 229.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreasislet of Langerhans   
    Nervousbraindiencephalonamygdala highly
     nerve   highly
    Reproductivemale systemtestis  highly
    Urinarykidney    
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one phosphatase 2C motif
  • one phosphatase domain
  • a cluster of glutamate residues and a cluster of proline residues
  • mono polymer heteromer , trimer
    HOMOLOGY
    intraspecies homolog to CAMKP
    Homologene
    FAMILY PP2C family of Ser/Thr protein phosphatases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • blocking the effects of PAK, and thus inhibiting actin stress fiber breakdown and morphological changes driven by cell division cycle 42
  • regulating the phosphorylation level of GAPDH in the CaMKP-GAPDH complex by dephosphorylating and deactivating CaMKs that are responsible for the phosphorylation of GAPDH
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • could form an heterotrimeric complex with PPM1F and PAK1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    manganese (Mn2+)
    protein interacting with PIX
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS