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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PEG10

contributors: mct/pgu - updated : 21-02-2012

HGNC name	paternally expressed 10
HGNC id	14005

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in a great majority of hepatocellular carcinomas tumoral     --over   from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia BCLL constitutional     --low   in third trimester downregulated in fetal samples group

Susceptibility

Variant & Polymorphism

Candidate gene	represents a novel marker in B-CLL
	for the treatment of hepatocellular carcinomas(development of drug(s) inhibiting PEG10 activity could be a novel approach)
Marker	positive expression of PEG10 or TSG101 is a predictor of poor prognosis in gallbladder adenocarcinoma
Therapy target
	System Type Disorder Pubmed cancer digestive liver for the treatment of hepatocellular carcinomas(development of drug(s) inhibiting PEG10 activity could be a novel approach)

ANIMAL & CELL MODELS